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Guess It Matters- S3 E3 How To Grow Your Audience

It is frustrating when you begin a new endeavor or with gospel music, your new ministry and you can’t seem to play in places where the people are. You spend all of your free time searching for material, maybe writing your own, and no one seems to be showing up to hear you? We have been there and we know that frustration. Honestly, your hard work away from the date you booked at a church or community center doesn’t just start and end with rehearsal. There are some other things you can do to help grow your audience and hopefully in the next few minutes we will give you a few tips that just might help. Please do us a favor and like and share our facebook, youtube and our podcasts wherever you are watching or hearing us – we would definitely appreciate it. Also, if you have a youtube channel please send us a link so we can check it out! Also, if you want us to evaluate your performance  you can send us a link to a youtube video or facebook live event and let us know that you want us to help you with your stage communication. At the end of the day – what matters to you – MATTERS to us!


Personality
All of us connect to an artist in some way or another. Their sound, their delivery, the song choices and how they conduct their interviews makes us want to meet them in person. We have all heard the stories and we may have some of our own where that artist was met away from the stage and the encounter wasn’t that great. They had a bad attitude or maybe they just acted like you were bothering them. All of a sudden you don’t like their music anymore. Personality is a key element to gaining a bigger audience. It’s the time you take getting to know the people that purchase your Cds or bring you something to eat. This is a sacred area of trust for the artist that should never be taken for granted or taken lightly. Now, we know there are some people that believe they are your biggest fan and they demand more than what is considered normal time. You need to develop a love for those around you that donate to what you do, book your programs or invite you to their communities or churches. It should never be shallow. If you want people to connect with the music you record you must must must connect with them on the same level. Because we simulcast our Podcast on the ourtupelo.com website I wanted to give an example of a couple people from different genres. The first is a gentleman named Matt Nolan. Matt is a rock and roll from the get go guy but he plays a lot of different types of music. One thing Matt does great outside of being a great musician is that he communicates with the people that come out to his shows around town. You constantly see him on Facebook asking his page followers what they want to hear at his next show. Next, he goes live from his venues and even interacts with his online friends that might not could make it. The guy plays nearly every venue in town that has live music. Another artist is a quartet from North Mississippi that have become really popular in a short amount of time. Their sincerity and music choices gets them invited to a lot of venues. I am talking about the Unity 4 Quartet from Iuka, MS. One thing that I absolutely love about these guys is their genuine love for the people that show up at their concerts. Their facebook page is filled with selfies with those that attend their concerts. The guys are naturally humbled by how everyone enjoys them. That connection is what helps.

From time to time we will be using other local examples and people that we have met over the years. I honestly don’t expect to pull any punches with some of the folks that we’ve opened for in the past. That brings us to our next tip –

KNOW Your audience 

How many times have we gone to hear a band or gospel group that may be a national touring artist and have to suffer through the opening act that forgot that everyone wasn’t there to see them? I’ve even seen bands or groups do covers of the people they are opening for! THAT IS A NO NO! If you are booked to open for someone keep in mind that this is an opportunity for you to introduce what you do to an audience that really didn’t come to hear you. You want to spend as much of your 20 minutes doing your best material and it best not be something the headliner recorded. You may get away with grace in a church somewhere and it may get people talking about your band – but I guarantee that it’s not positive talk. It’s Waffle House I can’t eat my pancakes without syrup coming out of my nose laughing at you, talk. Just don’t do that. Know the audience you are standing in front of at the moment. You were chosen to open and that’s what you need to do. The quartet that Michi and I sing with opened for the Nelons about a year ago and while everyone was gathering into the building a group of people stopped just inside the foyer. I was the only person there and one of them said, “Excuse me, but what time does the Nelons go on stage?” I said, “Well, the concert starts at 6.” They interrupted me and said, “I wasn’t talking about the warm-up group I don’t care about listening to them.” It never dawned on them that my face was on the poster. It didn’t bother me that much, I’ve been in that situation before. However, we knew we were there to be the opener and we sang our best songs that would allow the audience to participate in why were there to begin with and that was to have church. Even the Nelons got involved and had a good time and even invited us back on stage when it was over. If you know the audience isn’t in to what you are doing – don’t waste your time trying to win them over. They know within the first 2 songs whether they want to hang around or move on to something else. That happened with us once opening for another group. The crowd was more than ready for the concert to start and our style of music and the group we were opening for wasn’t the same by no stretch of the imagination. We were allotted 25 minutes as an opening group. Once the audience seemed to start enjoying what we were doing about 15 minutes into our set – I called it and we did our finale song and exited the stage. The church actually invited us back to a regular service that featured just us because they claimed we didn’t sing enough. We’ve gone back a few times since and have always had a good crowd to share our music with.

If you will work on those 2 things then you will be on your way to growing your audience. Don’t take advantage of relationships and don’t outstay your welcome. If this was a help to you- please like and share our post on facebook, and our podcast. Also, please subscribe to our youtube channel – shayandmichi. 

Unity March and Community Listening Session

TUPELO, Miss. — Northeast Mississippi residents plan to march from the Lee County Courthouse to Tupelo’s Fairpark Saturday, June, 6, and 2 p.m. to fight against inequality and injustice in our systems of government.

The group, led by activists at Indivisible Northeast Mississippi, are marching in solidarity with activists all over the world who want to see an end to the violent mistreatment of black- Americans at the hands of police.

“We know that people are hurting, people are angry and people just need to have an outlet to show that we care. I think that this protest that’s being led by Indivisible is giving people a sense of empowerment to do that, regardless of what race you might be.” said Teresa Roberts, an Indivisible Northeast Mississippi organizer.

At Fairpark, marchers, community members and elected officials will hear from guest speakers from the Northeast Mississippi community, including Dr. Richard Price, Tyson Quinn, Rev. Charles Penson, Father Phillip Parker, Cee Cee Jackson, and Marika Baliko, will speak about systemic racism, how it affects our communities, and what collective action can be taken to turn the tides.

Following the speakers, time will be made for open remarks from the community before Tupelo Mayor Jason Shelton closes the event with his response.

Indivisible Northeast Mississippi will provide sign materials and bottled water for marchers, and anyone wanting to offer written comments or register to vote can do so during the Fairpark listening session.

Since this even is taking place during the global COVID-19 pandemic, organizers require all participants wear face masks and maintain a safe social distance.

Indivisible Northeast Mississippi is part of a grassroots movement of thousands of local Indivisible groups with a mission to elect progressive leaders, rebuild democracy, and defeat the Trump agenda. The organization is nonpartisan and works to keep all elected officials — local, state and federal — accountable for their policies and votes.

All are welcomed to join protesters as they seek equality, inclusion and justice through action.

Demario Davis speaks passionately about nation’s ills, accepts Brees’ apology

Margaret Bowles via AP

Brandon’s Demario Davis has become one of the NFL’s most productive linebackers for the New Orleans Saints.

Yes, New Orleans Saints linebacker Demario Davis answers, he was dismayed Wednesday when he heard Drew Brees’ statement that Brees would “never agree with anybody disrespecting the flag of the United States” for any reason.

Brees’ statement seemed a not-so-veiled disparagement of his fellow NFL players who, in protest of police brutality against black people, have taken a knee during the playing of the national anthem. Brees’ statement was widely criticized, coming amid international marches and protests of the police killings of George Floyd in Minnesota, Breonna Taylor in Kentucky and Ahmaud Arbery in Georgia.

Rick Cleveland

“Drew and I have had a conversation about it,” Davis, a Brandon native, said in a telephone interview Wednesday morning. “I’ll keep what was said between us.”

But, having said that, Davis immediately praised Brees, the future Pro Football Hall of Famer, for the quarterback’s public apology Wednesday morning. In an Instagram post, Brees said his Tuesday remarks “were insensitive and totally missed the mark on what we are facing right now as a country.”

“I believe Drew’s apology is a model of the turn-around that needs to happen in this country right now,” Davis said. “For Drew to say that he missed the mark, that his remarks were insensitive, and that he’s going to start listening and learning from the black community and learning what he can do to help – that’s what needs to happen in America right now. That’s a model for all of America. That’s what we need. That’s true leadership. That’s taking ownership.”

Andy Kanengiser/MC

Drew Brees, speaking at Mississippi College in 2019.

Brees and Davis are two of the unquestioned leaders, on and off the field, of one of the NFL’s best teams. When Brees was injured and missed games during the 2019 season, Davis stepped into the quarterback’s role of leading the Saints’ pregame sideline chants meant to fire up the team. Both are also leaders in their communities.

Brees and his wife, Brittany, have given and raised millions for New Orleans and Louisiana causes. Davis has been active not only in Louisiana and in Mississippi but across the country for several different causes. Davis has given his time and money to causes such as immigrant rights at the Mexico-U.S. border, the water crisis in Flint, Michigan, as well as his own crusade against police brutality. In Jackson, Davis has raised money for St. Dominic Memorial Hospital, where his mother worked, with the sell of his “Man of God” bandannas.

Davis has said, many times, that as long as he has the platform of a popular pro football star on one of the NFL’s most popular teams, he plans to use it to work to make the world a better, kinder place. “I don’t care how much the world hates, I will always choose love,” he wrote on his Instagram account two years ago.

Davis, 31, spoke Wednesday from his home in Nashville. He also has a home in Brandon and splits his off-season time between Brandon, Nashville and New Orleans. He and his wife are the parents of three young children.

Davis spoke passionately in support of what he called “the worldwide protest of racism and the systematic suppression of black people.”

“The time is now,” Davis said. “We can’t get this wrong this time. This has gone on for 400 years in America. It’s time to stand up for black lives and putting an end to racism, which is woven into the fabric of our country and our state. It’s going to take all of us, no matter our color, our politics or anything else, doing our part, person by person, bit by bit. We need to fix what is wrong in Mississippi and around the country. We have to take a look deep down inside of ourselves. Every one of us.”

Davis went on: “I love my state. I am proud to represent Mississippi. Racism has affected and impacted Mississippi as much or more than it has any other place. It’s going to take all of us, doing our best, to fix it.”

The post Demario Davis speaks passionately about nation’s ills, accepts Brees’ apology appeared first on Mississippi Today.

‘Your life does not matter:’ Mississippi nurse writes Facebook post wishing death, jail time on protesters

CLARKSDALE — As people across the country protest to end police brutality and discriminatory policing practices against unarmed black people, a Northwest Mississippi Regional Medical Center nurse wrote a lengthy Facebook post calling protesters “thugs” and wishing violence and death upon them.

Lawrence Self

A now-deleted Facebook post from Monie Brown, a registered nurse in Clarksdale.

“What the hell is wrong with you people? People haven’t had a second thought about George Floyd and it is very clear because of all the rioting, looting, arson, destruction of property, beat downs and murder,” wrote Monie Brown, who is listed as a registered nurse according to Board of Nursing records.

In the post, Brown lashed out at rioters and protesters who are protesting the death of George Floyd, a black man who was killed by a police officer in Minnesota who kept his knee buried into his neck for more than eight minutes. In her post, Brown called the protesters “wild animals” and encouraged them to kill their own family members, burn their houses down and think about their actions.

“It is time we take this country back from you animals so be very careful about what your next step is because it can lead to 6 feet under! (President Donald) Trump is fixing to put your asses in jail or a grave. I hope it is the latter of the 2.”

In multiple posts, people in the Clarksdale community expressed outrage on social media, asking for others to report Brown’s actions and send emails and complaints to the Mississippi Board of Nursing and the local hospital where she works. Brown deactivated her Facebook page. Attempts to reach Brown were unsuccessful.

The Northwest Mississippi Regional Medical Center wrote a Facebook post on Thursday afternoon.

“Northwest Mississippi Regional Medical Center is committed to equality for all members of our community and strives to create an inclusive environment for employees to work and patients to receive care,” the statement said. “We serve the healthcare needs of patients and families of different backgrounds. All individuals in our facilities are to be treated with dignity and respect and we do not exclude people or treat them differently because of race, color, national origin, age, disability or sex.”

Mississippi Today reached out to the hospital directly, but has not received a response.

Coahoma County Supervisor Derrell Washington told Mississippi Today in a phone call that the Northwest Mississippi Regional Medical Center CEO Joel Southern confirmed to him that Brown was fired Thursday.

Brown’s words are not the first to stir controversy in the state, as multiple public officials have been chastised for speaking out about Floyd’s murder and ensuing protests. Earlier this week, Madison County prosecutor Pamela Hancock suggested on Facebook that “the deadly strain” of coronavirus should spread among rioters who are protesting inequity in the criminal justice system.

Last week, Petal Mayor Hal Marx posted on social, “If you can say you can’t breathe, you’re breathing,” and said Floyd likely died of an overdose or heart attack, multiple news outlet reported. Protesters are still demanding his resignation, the Hattiesburg American reported.

This week community organizers across the state in Clarksdale, Meridian, Jackson and Gulfport, among other towns and cities, are scheduling rallies and protests against police brutality, racism and discrimination as a way to honor the Black Lives Matter movement and the countless number of black people who has lost their lives to those very issues.

The post ‘Your life does not matter:’ Mississippi nurse writes Facebook post wishing death, jail time on protesters appeared first on Mississippi Today.

After court order, Mississippi releases list of nursing homes with active coronavirus outbreaks

Families who have been in the dark about coronavirus spread in their loved one’s nursing homes now have limited insight into facility outbreaks.

The state health department released a list of 116 facilities that have current outbreaks considered one case among residents and staff late Wednesday, after a judge ruled last week that the agency had to disclose the names.

In total, MSDH is reporting 1,718 resident cases, 1,003 employee cases and 310 resident deaths in long-term care facilities with active outbreaks. Of the 116 facilities with active outbreaks, 27 facilities about a quarter have only had one case among staff or residents, despite the disease’s quick-spread in residential facilities.

State Health Officer Thomas Dobbs said on Wednesday that facilities with proper infection control can either keep the virus out or keep it to minimal spread once it does come in, adding that a good rule of thumb in facilities is to assume everyone has it and protect staff and residents accordingly.

“We’ve seen places that had one employee (test positive) and had really great protocols for infection prevention and that was it – it just stopped,” he said. “That’s the kind of thinking we’re going to have to have going forward – we cant test our way out of it, though its an important tool – but combined with proper infection prevention we can do a good job.”

The list comes in the backdrop of drastic case growth over the last two weeks in Mississippi. New cases started to slow mid-May but have quickly reversed, worrying state officials particularly when it comes to not overburdening the health care system the goal of flattening the curve.

Active outbreaks maxed at 137 on Sunday, when the state tested all 211 facilities across the state. The number declining to 116 by Wednesday, as listed on the new facility list, means the state is considering some facilities recovered. On Wednesday, however, the state estimated 126 active outbreaks on their daily long-term care outbreak list by county – the source of the discrepancy is unclear. The case data is self-reported from facilities and is only as accurate as they report.

It’s still difficult to assess recoveries because cases are listed cumulatively for any facility or county with an outbreak, not differentiating between which cases within the facility might have recovered. Comparing the county list and new facility list, MSDH considered at least 275 residents 14 percent of all long-term cases over time recovered.

Ninety-five facilities are nursing homes, though nine developmental disability centers and six assisted living communities centers for aging adults but who live more independently than nursing homes also have active outbreaks. One personal care home and one “other” are also listed.

Hinds, Jones and Lauderdale counties are most represented on the list, each with seven facilities comprising 598 cases, almost a quarter of all cases among active outbreaks in the state. Central Mississippi, where five counties are still under shelter-in-place orders until Monday, has driven new cases recently and seen health care strain due to coronavirus spread and normal hospital use, according to Dobbs.

In Hinds, most long-term care cases are among residents, but in Jones and Lauderdale, cases are split fairly equally among staff and residents, echoing Dobbs’ point Wednesday to reporters that though there are still “significant” outbreaks in long-term care, they’re driven by staff and community spread, which can lead to hospital strain he says is happening in Jackson and the Pine Belt.

“We’re seeing more and more outbreaks associated with shrimp boils and parties,” Dobbs said, pointing to a “reverse scenario where people are bringing it into work because they’re catching it in the community.”

In Mississippi, facility outbreaks are not necessarily correlated with high community cases suggesting that it could be facility protocol that’s contributing to the spread as well, like Dobbs mentioned.  Of the 20 counties with the most COVID-19 cases per capita, only seven also have the most long-term care cases.

Facility outbreaks are also not driven by older age of a county’s population or high number of nursing homes. Only half of the counties with the most facilities also have the most long-term care cases, and even fewer just four counties with the most long-term care cases also have the highest proportions of those over the age of 75.

Still though, long-term care facilities are not driving the overall new case spikes seen across Mississippi over the last two weeks, nor are specific community outbreaks, says Dobbs. General community transmission folks spreading the virus at small or large gatherings by not socially distancing seems to be the main source of cases, Dobbs says.

That community spread lead to 12 days of steady new case growth late May to early June average new cases growing by nearly 20 percent in less than two weeks and surpassing unprecedented daily averages in the 300-new-case range for more than a week now. Over the same time, weekly case totals continued to peak for nine days, maxing out at 2,294 weekly cases on June 1 the most ever reported.

Over that time, an average of 4,500 daily viral tests were conducted, increasing total diagnostic tests by over 50 percent in two weeks, due largely in part to universal long-term care testing that just wrapped up. In total more than 62,000 Mississippians were tested over the last two weeks, not including antibody tests.

During the last two weeks of steady case growth, long-term care cases grew by 27 percent, while overall case growth grew by 34 percent.

Though older folks and those with weakened immune systems are most at risk of complications and still comprise most deaths and hospitalizations those over the age of 60 accounting for 87 percent of deaths and 61 percent of hospitalizations these trends are moving younger, a sign that community transmission is growing among asymptomatic people returning to normal activity.

Long-term care residents are still driving deaths, even while only accounting for 12 percent of all cases and 10 percent of new cases over the last two weeks.

As Dobbs mentioned Wednesday, new cases are diversifying by age. Younger people have driven new cases over the last two weeks 18 to 29-year-olds now accounting for majority cases, and their case-load growing by 57 percent in just two weeks.

The post After court order, Mississippi releases list of nursing homes with active coronavirus outbreaks appeared first on Mississippi Today.

Public retirees likely to lose ability to serve in Legislature without losing retirement benefits

Eric J. Shelton/Mississippi Today

Mississippi House speaker Philip Gunn speaks during Gov. Tate Reeves press conference at the State of Mississippi Woolfolk Building in Jackson, Miss., Thursday, May 7, 2020.

The board that governs Mississippi’s public employees retirement system could revisit and reverse its ruling that retired educators and state and local government retirees can serve in the Legislature while continuing to draw their pensions.

The Public Employees Retirement System Board had requested an IRS ruling on whether its decision could negatively impact the federal tax exempt status of the system, which could be detrimental for the system and its members.

The board had voted in 2019 to change its regulation to allow the public retirees to serve in the Legislature and draw their pension as they do in other states, such as Florida. But in making the change, board members said they needed approval of the IRS.

In a letter sent to the PERS Board in early May, officials at the IRS said: “In this particular instance we have determined that we cannot issue a ruling based on the factual nature of the matter involved.”

When contacted, the IRS refused to provide any additional details. And PERS officials only referenced the letter and indicated the issue would be discussed by its governing board as early as its next regular meeting on June 23.

Members of the House leadership believe the IRS ruling – or lack of ruling – means that the PERS Board will have to reverse its ruling allowing public retirees to serve in the Legislature and draw their pension or risk losing the tax exempt status.

“My understanding of the issue is the absence of the IRS endorsement changes everything,” said House Speaker Philip Gunn, R-Clinton. “It puts the tax exempt status of the plan in jeopardy.”

House Pro Tem Jason White, R-West agreed. He said if a request is made and the request is not granted: “Isn’t it the same as saying you can’t do that?”

The House leadership has opposed the change in regulation to allow public retirees to serve and draw their pension from the very beginning. Gunn argued the PERS change conflicted with existing state law.

For years, PERS’ regulations prevented public employees from serving in the Legislature and drawing their pension. But in late 2018, former Attorney General Jim Hood issued an opinion – based on a question from an elective official – saying that public employees could serve in the Legislature and draw their pension as long as they received only a portion of their legislative pay. Public employee retirees already can work part time for other governmental agencies. Hood ruled that they also should be allowed to serve in the Legislature.

In the 2019 election, four public retirees – all Republicans – were elected to the House with the expectation that they could draw their pension while receiving partial legislative pay. But the House leadership – despite the PERS change in regulation – refused to reduce the pay of the four members, meaning they were ineligible to receive retirement pay.

Two of the four members – Ramona Blackledge, former Jones County tax assessor/collector, and Billy Andrews, former Lamar County judge – already have stepped down from the legislative seats. The other two, Jerry Darnell of DeSoto County and Dale Goodin of Richton, both retired educators, are still serving and forgoing their monthly retirement benefits.

“It will eventually be resolved,” Goodin said. “You can’t continue to take people’s rights away.” Goodin and others have argued not allowing retired public employees to serve and draw their pension takes away a right from them that others, such as retirees from the private sector, have.

When PERS board members changed the regulation, they did so with the understanding that they might have to rescind the change if not approved by the IRS.

Retired public employees in other states are allowed to serve in their legislatures without their system being penalized by the IRS. The four elected officials told Mississippi Today this year that they do not understand why Mississippi is different.

For instance, Florida law says specifically “any retired state employee who is presently drawing retirement benefits under any state retirement system may, as any other citizen, serve in the Legislature without affecting in any way his or her retirement status or the receipt of retirement funds while a member of the Legislature.”

PERS Executive Director Ray Higgins said earlier the IRS might allow public employee retirees to serve in the legislature in other states without losing their pension and not allow it in Mississippi because “each state has different laws, regulations, and retirement plan designs.”

Most employees of state and local governments, public schools K-12 and university employees, participate in Mississippi’s retirement system, contributing 9 percent of their salary for retirement benefits.

According to PERS data, the average benefit is more than $23,100 annually for the more than 100,000 people drawing benefits. In total, more than 300,000 are in the public employees retirement system either drawing benefits, having paid into the system or currently paying into the system.

The post Public retirees likely to lose ability to serve in Legislature without losing retirement benefits appeared first on Mississippi Today.

Weekend Forecast

FRIDAY: A 40% chance of showers and thunderstorms. Otherwise, it will be a mix of sun & clouds, with a high near 89. West wind around 5 mph.

FRIDAY NIGHT: Partly cloudy, with a low around 71.

SATURDAY: A slight chance of showers and thunderstorms in the afternoon. Otherwise, it will be mostly sunny, with a high near 92.!Calm wind becoming east northeast around 5 mph.

SATURDAY NIGHT: Partly cloudy, with a low around 71.

SUNDAY: A mix of sun & clouds with a high near 92!. East northeast wind 5 to 10 mph.

COVID-19 Data: Day-of-death

While the state health department publishes new deaths each day, those reports are not necessarily from the previous day. This chart uses day-of-death data, reported by the health department after COVID-19 death investigations, to show the date that each death happened, both in long-term care settings and the general population.

Though long-term care residents are not driving overall new case growth, they are comprising most COVID deaths in the state — currently accounting for 52 percent of all deaths and accounting for nearly two-thirds of all deaths over the last two weeks. Late-May, the state completed universal long-term care facility testing of every resident and staff, accounting for nearly 27,000 tests.

Learn more about long-term care cases here.

The post COVID-19 Data: Day-of-death appeared first on Mississippi Today.

Artificial Kidneys Are a Step Closer With This New Tech

10 percent of the global population suffers from some form of kidney disease. That includes 37 million people in the US, 100,000 of whom pass away each year awaiting a kidney transplant.

Our kidneys are crucial for keeping us alive and healthy. A sort of chemical computer that keeps our blood chemistry stable—whether we’re eating a sugary birthday cake or a vitamin-filled salad—they prevent waste buildup, stabilize our electrolyte levels, and produce hormones to regulate our blood pressure and make red blood cells.

Kidneys clean our blood using nephrons, which are essentially filters that let fluid and waste products through while blocking blood cells, proteins, and minerals. The latter get reintegrated into the blood, and the former leave the body in urine.

Scientists have struggled to come up with viable treatments for kidney disease and renal failure, and their complexity means kidneys are incredibly hard to synthetically recreate; each kidney contains around one million intricately-structured nephrons.

But new progress from chemical engineering researchers at the University of Arkansas has brought functioning artificial kidneys one step closer. The researchers created a device that was able to filter blood in a way similar to biological nephrons. They described the device in a recent paper published in Nature Communications Materials.

There are two basic processes that take place when blood passes through the kidneys. First, clusters of blood vessels called glomeruli let small molecules, waste, and water through, while proteins and blood cells stay behind. The material that gets through this first filter then flows into the nephron network, where it’s further filtered in a process called ion transport.

The researchers’ work focused on the second step, ion transport. They placed a porous mesh made of platinum between two ion-exchange wafers to create a wafer that pushes ions through membranes using an electric field. The platinum meshes serve as electrodes when voltage is applied, enabling the team to select different ions and adjust their transport rates independently. They tested the technology with various ions and were successfully able to mimic the ion transport done by the kidneys.

In their paper, the team points out that other research groups have tried creating artificial nephrons using living, cell-based systems, including stem cells; but outside a native, living environment and absent the physical and hormonal signaling that control their function, biologically-based systems have struggled to replicate the nephrons’ function, especially ion transport.

Christa Hestekin, Arkansas associate professor of chemical engineering and the lead author of the paper, said, “The system could work as a stand-alone device or in conjunction with peritoneal dialysis to control the chemistry of solutions used in treatment. And, minor modifications to the device could enable it to function as a wearable and potentially implantable artificial kidney.”

In the US alone, over 93,000 people are currently on the waiting list for a kidney transplant. Though a fully-functioning artificial kidney is likely still years away at best, scientists are making incremental progress in recreating this vital organ; an artificial nephron like the one described here is just one piece of a complex puzzle.

Another crucial piece is a functioning network of blood vessels. In 2015, scientists at Lawrence Livermore National Laboratory created bioprinted kidney tissue that replicated some of the functions of biological nephrons. In 2016 a group at Harvard’s Lewis Lab used 3D printing to re-create the nephrons’ tubules, complete with a vascular network for blood flow—but they only stayed alive for a little over two months.

The fully synthetic nature of the Arkansas team’s technology could thus have a leg up on biologically-based approaches. According to Hestekin, the nephron could be combined with ultrafiltration, nanofiltration, or reverse osmosis systems and integrated into an artificial kidney.

Given the vast number of people in need of them, artificial kidneys can’t come soon enough, and will be a miracle of modern science when they do arrive. Though it’ll be some time yet, incremental progress like this gives us the confidence to say “when” instead of “if.”

Image Credit: crystal light / Shutterstock.com